SERCA Cys sulphonylation and inhibition of L-type Ca influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis
نویسندگان
چکیده
Ion A. Hobai, Emmanuel S. Buys, Justin C. Morse, Jessica Edgecomb, Eric H. Weiss, Antonis A. Armoundas, Xiuyun Hou, Alok R. Khandelwal, Deborah A. Siwik, Peter Brouckaert, Richard A. Cohen, and Wilson S. Colucci Cardiovascular Medicine Section, Department of Medicine, Boston University Medical Center, Boston, Massachusetts; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Vascular Biology Section, Department of Medicine, Boston University Medical Center, Boston, Massachusetts; and Department of Biomedical Molecular Biology, Ghent University, and Department for Molecular Biomedical Research, Flanders Institute for Biotechnology, Ghent, Belgium
منابع مشابه
SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis.
The goal of this study was to identify the cellular mechanisms responsible for cardiac dysfunction in endotoxemic mice. We aimed to differentiate the roles of cGMP [produced by soluble guanylyl cyclase (sGC)] versus oxidative posttranslational modifications of Ca(2+) transporters. C57BL/6 mice [wild-type (WT) mice] were administered lipopolysaccharide (LPS; 25 μg/g ip) and euthanized 12 h later...
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